Search results for "biophysical modeling"

showing 2 items of 2 documents

Prediction of CRT Activation Sequence by Personalization of Biventricular Models from Electroanatomical Maps

2020

[EN] Optimization of lead placement and interventricular delay settings in patients under cardiac resynchronization therapy is a complex task that might benefit from prior information based on models. Biophysical models can be used to predict the sequence of electrical heart activation in a patient given a set of parameters which should be personalized to the patient. In this paper, we use electroanatomical maps to personalize the endocardial activation of the right ventricle, and the different tissue conductivities in a pig model with left bundle branch block, to reproduce personalized biventricular activations. Following, we tested the personalized heart model by virtually simulating card…

Cardiac resynchronization therapySequencemedicine.medical_specialtyComputer scienceLeft bundle branch blockmedicine.medical_treatmentCardiac resynchronization therapyPig modelmedicine.diseasePersonalizationTECNOLOGIA ELECTRONICATissue properties personalizationmedicine.anatomical_structureVentricleInternal medicinemedicineCardiology03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edadesIn patientLead PlacementBiophysical modeling
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Data from: Genome architecture enables local adaptation of Atlantic cod despite high connectivity

2017

Adaptation to local conditions is a fundamental process in evolution; however, mechanisms maintaining local adaptation despite high gene flow are still poorly understood. Marine ecosystems provide a wide array of diverse habitats that frequently promote ecological adaptation even in species characterized by strong levels of gene flow. As one example, populations of the marine fish Atlantic cod (Gadus morhua) are highly connected due to immense dispersal capabilities but nevertheless show local adaptation in several key traits. By combining population genomic analyses based on 12K single nucleotide polymorphisms with larval dispersal patterns inferred using a biophysical ocean model, we show…

medicine and health carePopulation Divergencechromosomal inversionLife SciencesMedicinebiophysical modeling
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